As a grinding monster, diabetes has not let go of the common people in every corner of the society. In China, there is one prediabetic patient in every 2 adults and one diabetic patient in every 10 adults. Moreover, nearly 70% of sugar friends' patients do not meet the blood glucose control standard. In the long run, they are prone to islet failure and rely on insulin injection.
However, new hypoglycemic drugs are constantly being developed. For example, in recent years, scientists have developed a new type of oral hypoglycemic drugs: "glibenclamin" hypoglycemic drugs have been widely used in foreign countries and have been listed in China Dapaglezin (andatang), englizin (otanjin), kagliclazin (econam). If there are sugar friends who are already using this kind of drug, they should have experienced it. Before that, they have been paying for it, but it is said that daggligin will soon enter medical insurance.
Do not rely on insulin hypoglycemic, long-term disease, sugar friends should look forward to it
Insulin is in our bodies The only hormone that directly lowers blood sugar In most cases, insulin is administered directly or indirectly to patients with advanced diabetes. Is there any way to get rid of insulin to lower blood sugar? Scientists really find a way
——Let you "pee" the extra sugar!
The tubule of normal person kidney can excrete about 160 ~ 180 g glucose every day, more than 3 Liang! But why do normal people have no urine sugar? Because the kidney has a "diligent Mr." code named sglt-2, it absorbs the filtered sugar into the blood, so as not to waste energy.
The kidney is made up of these glomeruli. The red ones are blood vessels that filter waste into the Yellow sac
As long as this "diligent Mr." does less work, the sugar will be discharged with a large amount of urine, and the blood sugar will be low? ---Scientists have to think about it.
The scientists found that the SG2 drug, which does not inhibit glucose excretion from the urine of patients with diabetes, can reduce the blood glucose excretion of this type 2 drug.
This kind of new drugs sugar effect is very good, take the example of kaglitazone, 100 mg a day, about 100 g Sugar. "It's equivalent to 6 liang of rice or 13000 steps. "
The effect of these drugs has nothing to do with insulin secretion and insulin action. It can be used as a single drug or combined with other oral hypoglycemic drugs or insulin.
In addition to hypoglycemic effects, gliclagin has additional benefits
In recent years, the research of glibenclamide is very popular. The main reason is that they not only control sugar, but also protect cardiovascular and kidney. Let's analyze the characteristics of these drugs.
1. The effect of glucose control is similar to that of metformin, and does not increase the risk of hypoglycemia
The results of a 12-78 week clinical study showed that in HbA1c, 7.5% - 9.2% of Tangyou, The three kinds of glitazin drugs can reduce the glycosylated hemoglobin by 0.7%, It has nothing to do with the combined hypoglycemic drugs. A study on type 2 diabetes mellitus in Asia found that daglipin reduced HbA1c by 1.16%, reduced fasting blood glucose by 1.9 mmol / L and 2-hour postprandial blood glucose by 3.2 mmol / L, with a compliance rate of 52.5%.
Taking metformin, an old oral hypoglycemic drug, as an example, Professor r.r.henry of the University of California conducted a 24 week clinical trial on newly diagnosed type 2 diabetes mellitus patients aged 18-77 years. The results showed that the effect of dapagliptin 10mg was similar to that of metformin 2000mg in reducing HbA1c, but it had better effect on fasting blood glucose (FPG).
When combined with insulin, glibenclamide can further reduce HbA1c, reduce insulin dosage for injection and reduce body weight, and do not increase hypoglycemia.
2. Patients with cardiovascular diseases are suitable for gliclagin
Information: A study of 7020 patients with type 2 diabetes mellitus with cardiovascular disease found that the risk of cardiovascular death, myocardial infarction and stroke was reduced by 14%, and the risk of hospitalization for heart failure was reduced by 35%. Therefore, in December 2016, FDA approved the indications for cardiovascular protection in patients with type 2 diabetes mellitus.
List: In the canvas study, 10000 patients with type 2 diabetes from more than 30 countries were included in the study. It was found that the risk of cardiovascular disease was reduced by 14% and the risk of hospitalization for heart failure was reduced by 33%.
Details: According to the declare TIMI study, daggliptin reduced the risk of hospitalization for heart failure or death from cardiovascular causes by 17%.
3. Gliquid is also the gospel of diabetic nephropathy sugar friends
According to the declare TIMI study, the incidence and deterioration of renal disease in patients with daseglinin were reduced by 24%; the risk of death caused by uremia and nephropathy was reduced by 40%; the incidence of new onset or deterioration of kidney disease was reduced by 39%, and the mortality caused by renal transplantation or nephropathy was reduced by 46%.
(for professional research, the text is a little awkward. Please forgive me. I've tried my best to adjust it to be popular. In fact, it's good for sugar friends to understand.)
There are always advantages and disadvantages. As a new drug for controlling glucose, gliclagin has a relatively short time to market, and whether there are hidden side effects can not be completely ruled out. In addition, it should be noted that, after all, there is a large amount of sugar in the urine, which may cause urinary tract infection. Tangyou should keep the vulva clean and dry during medication, and be alert to urinary tract infection and reproductive system infection. Once it happens, please as soon as possible See a doctor.
The use of any hypoglycemic drugs, are inseparable from the sugar friends with their own lifestyle adjustment. At present, although glibenclamide is good, it is not enough to rely on it. The five carriages of diabetes treatment can not be neglected. And the medicine ultimately depends on the doctor to judge whether it is suitable for use according to the situation. As sugar friends, we need to do a good job in the daily sugar control strategy in addition to drugs.
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